Preliminary research indicates that cannabidiol may reduce adverse effects of THC, particularly those causing intoxication and sedation, but only at high doses. Safety studies of cannabidiol showed it is well-tolerated, but may cause tiredness, diarrhea, or changes in appetite as common adverse effects. Epidiolex documentation lists sleepiness, insomnia and poor quality sleep, decreased appetite, diarrhea, and fatigue.
CBD interacts with the body through the endogenous cannabinoid system (ECS) or endocannabinoid system. First discovered in the late 1980’s, the endocannabinoid system regulates the body’s homeostasis, or general state of balance, impacting such functions as mood, sleep, appetite, hormone regulation, and pain and immune response. Like an acrobat on a highwire, as the environment around us impacts our normal balance, the endocannabinoid system “corrects” by mediating our body’s reaction to keep us level.
My order has shipped and should be here on the 31st. I am so excited. I got an anoxic brain injury during an open heart surgery. Since then I have had an amazing amount of muscle and nerve pain. I ordered the 500mg bottle. I was told to start low and go higher if I need it. So excited to receive it. I am praying it works for my pain. I will let you know my progress. Thank You
Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain. It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12. Although currently classified as orphan receptors, these receptors are most closely related phylogenetically to the cannabinoid receptors. In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist, and this action may be involved in its antidepressant, anxiolytic, and neuroprotective effects. It is an allosteric modulator of the μ- and δ-opioid receptors as well. The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.
The 3000 tincture has been very helpful for me with: chronic & acute wide spread pain, headaches, anxiety, sleep, nausea, & allergies....not a complete cure, but a tremendous help with all of these, & with absolutely no side effects (& I am extremely susceptible to any side effects from meds & some supplements)....very happy to have found this product.
Medterra is the only CBD brand I order from. I was a little skeptical about CBD at first but tried it on the advice of my doctor. I suffer from chronic pain and the only thing that helps the pain is this oil. It really helps with my back pain and I use the tincture and the new Cooling Cream. And the best part is that there are no side effects I dont feel drowsy or unfocused and it doesnt interact with other medications. And Medterra is a fantastic company. One time the shipping of my oil was delayed for some reason and they sent it using express shipping without an added cost Their service is great.
By popular demand, we have also begun to carry several, high quality CBD pet products as well. For general purpose applications, we carry several, tasty tincture and oral spray options that are highly effective. Likewise, Pharma CBD capsules provide CBD purity via capsular ingestion. In addition, we have partnered with Therabis, the quality CBD maker of “Stop the Itch” and “Calm and Quiet”, the pet lovers’ ultimate go-to’s. Find these products by browsing our exclusive online inventory.
In the USA the legal definition of “industrial hemp,” per Section 7606 of the Agricultural Appropriations Act of 2014, is “INDUSTRIAL HEMP — The term ‘‘industrial hemp’’ means the plant Cannabis sativa L. and any part of such plant, whether growing or not, with a delta-9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis.”
I am very impressed with this CBD oil. I tried other brands with lower dosage and was not really happy. This dosage seems to work great for me, I have a crunched vertebrae from a quad wreck, and the mornings have always been the worst. Within a day I was already noticing great relief. I have contacted Medterra a few times and each time they were quick to respond and very helpful. I will always do my CBD business with this company!